Research Projects

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1. Development of therapeutic vaccination protocol for human tumors;

2. Verification of expression profiles gence of patients with myelodysplastic syndrome;

3. ARHGAP10 and functional assessment of new therapies in myelodysplastic syndromes;

4. Culture of mesenchymal cells derived from adipose tissue (ADSC), neuronal differentiation and marked with super-paramagnetic nanoparticles;

5. Investigation of biological and pharmacological effects of quercetin in cells from patients with myelodysplasia and acute myeloid leukemia;

6. Differentiation of stem cells obtained from adipose tissue (ADSC) in chondrocytes using collagen type II as a support for cartilage repair;

7. The influence of different media culttura serum-free generation of dendritic cells in the pair immunotherapy treatment of patients with acute myeloid leukemia;

8. Differential expression and function of IRS1 in myelodysplasia and acute leukemia;

9. Comparative analysis of proteome and xecretoma of mesenchymal stem cells obtained from umbilical cord blood and adipose tissue during hepatocytic lineage differentiation;

10. Influence of CYP2B6 polymorphisms, G15631T, GSTM1, GSTT1, MDR-1, NQO1 C345T and C609T in response to treatment of acute leukemia and myelodysplastic syndrome;

11. Expression and function of CXCR7 in myelodysplastic syndromes and leukemias;

12. Immunotherapy as a tool for modulation of adaptive immune response in anti-tumor hematologic malignancies;

13. Participation of ARHGAP21 in migration and adhesion of hematopoietic progenitor cells in bone marrow niches;

14. Study of P53 mutations and PTPN 11 in Myelodysplastic Syndrome. “/ Expression study of genes PR1, WT1 and PRAM in myelodysplastic syndromes;

15. Analysis of Response to Treatment Remission Induction in Non-Hodgkin lymphomas with Gene Polymorphism in the MDM2 SNP309;

16. Analysis of gene expression and FAK ARHGAP21 in myelodysplasia;

17. Expression of tumor antigens in acute myeloid leukemia: a basis for immunotherapy;

18. Repetitions of the tri-nuceotídeo GAA in the frataxin gene in patients with myelodysplasia (MDS);

19. Investigation of the expression of inhibitors of metalloproteinases and ligand stromal derived factor 1 in myelodysplasia and acute leukemia;

20. Study of the signaling pathway of BMI-1 in bone marrow biopsies of patients with myelodysplasia and acute myeloid leukemia;

21. Investigation of Hedgehog pathways in acute myeloid leukemia and myelodysplastic syndromes;

22. Study of protein expression of ARHGAP21 and B-catenin in cells with no A-catenin;

23. Functional characterization of CATS protein and its role in cell proliferation and the genesis of leukemia;

24. Thermodynamic characterization and structural protein interactions involved in signaling pathways of hematopoiesis by isothermal titration calorimetry (ITC) and x-ray scattering Small angle (SAXS);

25. Functional characterization of ANKHD1, a new protein in multiple mieoloma;

26. Mesenguimais obtained using cells from human adipose tissue and umbilical cord in the differentiation of hepatocytes and bile ducts;

27. Identification of polymorphisms in patients with sickle cell anemia and beta-thalassemia and homozygous silencing and overexpression in cultured erythroid gene SARA2;

28. Profile analysis of miRNAs and transcription factors involved in erythropoiesis in vitro in patients with intermediate beta-thalassemia and sickle cell anemia;

29. Functional evaluation of eosinophils in sickle cell disease and the effect of treatment with hydroxyurea;

30. Shares of Protein GATA1s Differentiation in Hematopoietic Cell Lineage;

31. Molecular mechanisms related to differential expression gence in patients with hereditary persistence of fetal hemoglobin type delecional non-Brazilian;

32. Analysis of gene expression of AHSP and human globin chains in thalassemic patients and carriers of the mutation N75I AHSP;

33. Functional analysis of genes EYA3, and HES6 LXn during erythroid differentiation and beta thalassemia and in patients with sickle cell anemia;

34. Expression and function of adhesion molecules in neutrophils from patients with hemolytic anemia;

35. Iron metabolism in hematopoietic cells in hemoglonopatias and states of iron overload;

36. Moelcualres mechanisms and cellular phenomena associated with inflammatory and regulating the production of fetal hemoglobin in the hemoglobinopathies: investigation of new therapies in vitro and Animasivo transfênicos pilot study in humans;

37. Effect of simvastatin and sildenafil in the inflammatory process in sickle cell disease: a randomized pilot study, single-blind, placebo-controlled animal model and patients;

38. Assessment of copy number variations (CNVs) in susceptibility to stroke in patients with sickle cell anemia;

39. Preclinical study of the efficiency of stem / progenitor cells from bone marrow of mice with chronic peripheral arterial disease induced angiogenesis in ischemic limbs of mice;

40. Evaluation of ADAMTS13 in Brazilian patients with thrombotic thrombocytopenic purpura;

41. Association of gene polymorphisms of IL-1, IL-4, IL-8 and IL-10 with the clinical response of patients with immune thrombocytopenia purpura;

42. Evaluation of ADAMTS13 activity in venous thromboembolism;

43. Assessment of receptor expression gency liver LRP and FVIII and their correlation with plasma levels of FVIII and vWF;

44. Analysis of gene expression profile of inflammatory mononuclear cells meters deep venous thrombosis;

45. Arterial and venous vascular disease: pathophysiology, identification of new risk factors and gene therapy.

46. Characterization of Alpha-Thalassemia Delecional by MLPA (Multiplex Ligation-Dependent Amplification).

47. Clinical and laboratory aspects of sickle cell disease in patients from Rio Grande do Norte.

48. Aspects of Inflammatory versus Haptoglobin Genotype and Presence CCR5D32 Polymorphism in sickle cell disease.

49. Structural Studies and Molecular Dynamics of Human Hemoglobin Variants.

50. Análisis molecular del cluster of genes of beta-globin la población en la uruguaya. Hemoglobinopathies, and imbalance of ligamiento recombinational history.

51. Gene silencing PIPKIIA Enzyme in Normal Human Erythroid Cells and Disease Patients with Hb H.

52. Silencing of the beta globin gene in Erythroid Cell Culture of Patient with Hb H Disease

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